Peer Reviewed Publications

GERD Surgery

Functional Lumen Imaging Probe to Assess Geometric Changes in the Esophagogastric Junction Following Endolumenal Fundoplication.
Hoppo T, McMahon BP, Witteman BP, Kraemer SJ, O’Rourke RW, Gravesen F, Bouvy ND, Jobe BA.
Journal of Gastrointestinal Surgery 2011:15(7) 1112-1120

Esophagogastric Junction Distensibility After Fundoplication Assessed with a Novel Functional Luminal Imaging Probe
Monika A. Kwiatek, Peter J. Kahrilas, Nathaniel J. Soper, William J. Bulsiewicz, Barry P. McMahon, Hans Gregersen and John E. Pandolfino
Journal of Gastrointestinal Surgery 2009:13(12) 2219-2225

Adult esophagogastric junction distensibility during general anesthesia assessed with an endoscopic functional luminal imaging probe (EndoFLIP)
Dr. Leslie K. Nathanson, Nathan Brunott, David Cavallucci
Surgical Endoscopy 2012:26(4) 1051-5

Feasibility of esophagogastric junction distensibility measurement during Nissen fundoplication
A. Ilczyszyn and A. J. Botha
Dis Esophagus. 2014 Sep-Oct;27(7):637-44

Effect of transoral incisionless fundoplication on reflux mechanisms
Rinsma NF, Smeets FG, Bruls DW, Kessing BF, Bouvy ND, Masclee AA, Conchillo JM.
Surg Endosc. 2014 Mar;28(3):941-9

Acta from the EndoFLIP(R) Symposium

Perretta S, McAnena O, Botha A, Nathanson L, Swanstrom L, Soper NJ, Inoue H, Ponsky J, Jobe B, Marescaux J, Dallemagne B.
Surg Innov. 2013 Dec;20(6):545-52

Long-term effects of anti-reflux surgery on the physiology of the esophagogastric junction

Kessing BF, Bredenoord AJ, Schijven MP, van der Peet DL, van Berge Henegouwen MI, Smout AJ.
Surg Endosc. 2015 Dec;29(12):3726-32

Does Measurement of Esophagogastric Junction Distensibility by EndoFLIP Predict Therapy- responsiveness to Endoluminal Fundoplication in Patients With Gastroesophageal Reflux Disease?

Smeets FG, Keszthelyi D, Bouvy ND, Masclee AA, Conchillo JM.
J Neurogastroenterol Motil. 2015 Mar 30;21(2):255-64.

Measurement of Esophagogastric Junction Distensibility May Assist in Selecting Patients for Endoluminal Gastroesophageal Reflux Disease Surgery and Authors reply

Dea J. and Smeets FG, Keszthelyi D, Masclee AA, Conchillo JM.
J Neurogastroenterol Motil. 2015 Jul 30;21(3):448-51.

Esophagogastric junction distensibility is greater following Toupet compared to Nissen fundoplication.

DeHaan RK, Davila D, Frelich MJ, Gould JC.
Surg Endosc. 2016 Apr 29. [Epub ahead of print]

Achalasia Surgery

Efficacy of Treatment for Patients with Achalasia Depends on the Distensibility of the Esophagogastric Junction
Rohof, W.O., Hirsch, D.P., Kessing, B.F., Boeckxstaens, G.E.
Gastroenterology 2012:143(2) 328-35


Improving functional esophageal surgery with a “smart” bougie: endoflip
Silvana Perretta, Bernard Dallemagne, Barry McMahon, Jacopo D’Agostino and Jacques Marescaux
Surgical Endoscopy 2011: 25(9) 3109


Transoral endoscopic esophageal myotomy based on esophageal function testing in a survival porcine model
Perretta S, Dallemagne B, Donatelli G, Diemunsch P, Marescaux J
Gastrointestinal Endoscopy 2011:73(1) 111-6


Intraoperative assessment of esophagogastric junction distensibility during per oral endoscopic myotomy (POEM) for esophageal motility disorders
Rieder E, Swanström LL, Perretta S, Lenglinger J, Riegler M, Dunst CM.
Surgical Endoscopy 2013:27(2) 400-5


Distensibility of the esophagogastric junction assessed with the functional lumen imaging probe (FLIP™) in achalasia patients
Pandolfino JE, de Ruigh A, Nicodème F, Xiao Y, Boris L, Kahrilas PJ.
Neurogastroenterol Motil. 2013 Jun;25(6):496-501


Effect of peroral endoscopic myotomy on esophagogastric junction physiology in patients with achalasia
T Verlaan, WO Rohof, AJ Bredenoord, S Eberl, T Rösch, P Fockens
Gastrointestinal Endoscopy 2013 78(1):39-44


POEM: Way to go!
Swanstrom LL.
Gastrointest Endosc. 2013 78(1):45-6.


Comparison of esophagogastric junction distensibility changes during POEM and Heller myotomy using intraoperative FLIP
Teitelbaum EN, Boris L, Arafat FO, Nicodème F, Lin Z, Kahrilas PJ, Pandolfino JE, Soper NJ, Hungness ES.
Surg Endosc. 2013 27(12):4547-55


EndoFLIP system for the intraoperative evaluation of peroral endoscopic myotomy  
Familiari P, Gigante G, Marchese M, Boskoski I, Bove V, Tringali A, Perri V, Onder G Costamagna G.   
United European Gastroenterology J. 2014 Apr;2(2):77-83


An extended proximal esophageal myotomy is necessary to normalize EGJ distensibility during Heller myotomy for achalasia, but not POEM.
Teitelbaum EN, Soper NJ, Pandolfino JE, Kahrilas PJ, Boris L, Nicodème F, Lin Z, Hungness ES.
Surg Endosc. 2014 28(10):2840-7.


Esophagogastric junction distensibility measurements during Heller myotomy and POEM for achalasia predict postoperative symptomatic outcomes.          
Teitelbaum EN, Soper NJ, Pandolfino JE, Kahrilas PJ, Hirano I, Boris L, Nicodème F, Lin Z, Hungness ES.
Surg Endosc. 2015 29(3):522-8


Per-oral endoscopic myotomy: Major advance in achalasia treatment and in endoscopic surgery
Friedel D, Modayil R, Stavropoulos SN
World J Gastroenterol. 2014 20(47):17746-17755.  


Intraoperative distensibility measurement during laparoscopic Heller’s myotomy for achalasia may reduce the myotomy length without compromising patient outcome
Ilczyszyn, K. Hamaoui, J. Cartwright, A. Botha
Dis Esophagus. 2016 Jul;29(5):455-62


The effect of incremental distal gastric myotomy lengths on EGJ distensibility during POEM for achalasia
Teitelbaum EN, Sternbach JM, El Khoury R, Soper NJ, Pandolfino JE, Kahrilas PJ, Lin Z, Hungness ES.
Surg Endosc. 2016 Feb;30(2):745-50


Intraoperative measurement of esophagogastric junction cross-sectional area by impedance planimetry correlates with clinical outcomes of peroral endoscopic myotomy for achalasia: a multicenter study
Ngamruengphong S, von Rahden BH, Filser J, Tyberg A, Desai A, Sharaiha RZ, Lambroza A, Kumbhari V, El Zein M, Abdelgelil A, Besharati S, Clarke JO, Stein EM, Kalloo AN, Kahaleh M, Khashab MA
Surg Endosc. 2016 Jul;30(7):2886-94


Endoscopic treatment for iatrogenic achalasia post-laparoscopic adjustable gastric banding
Pescarus R, Sharata A, Shlomovitz E, Reavis K, Dunst C, Swanstrom L
Surg Endosc. 2016 Jul;30(7):3099


Intraoperative Assessment of Esophagogastric Junction Distensibility During Laparoscopic Heller Myotomy.
DeHaan RK, Frelich MJ, Gould JC.

Upper GI Imaging

Measuring Mechanical Properties of the Esophageal Wall Using Impedance Planimetry
Moonen A, Boeckxstaens G
Gastrointest Endosc Clin N Am. 2014 Oct;24(4):607-18


Esophagogastric junction distensibility assessed with an endoscopic functional luminal imaging probe (EndoFLIP®)
Monika A. Kwiatek, PhD, John E. Pandolfino, MD, Ikuo Hirano, MD, Peter J. Kahrilas, MD
Gastrointestinal Endoscopy 2010:72(2) 272-278


Mechanical Properties of the Esophagus in Eosiniphilic Esophagitis
Monika A. Kwiatek, Ikuo Hirano, Peter J. Kahrilas, Jami Rothe, Daniel Luger, John E. Pandolfino
Gastroenterology 2011:(140)82-90


Functional luminal imaging probe topography: an improved method for characterizing esophageal distensibility in eosinophilic esophagitis
Z Lin, PJ Kahrilas, Y Xiao, F Nicodeme, N Gonsalves, I Hirano, JE Pandolfino
Therapeutic Advances in Gastroenterology 2013:(6) 97-107


New measures of upper esophageal sphincter distensibility and opening patterns during swallowing in healthy subjects using EndoFLIP
Regan, M Walshe, N Rommel, J Tack, BP McMahon
Neurogastroenterol Motil. 2013 Jan;25(1):e25-34


Endoflip® evaluation of pharyngo-oesophageal segment tone and swallowing in a clinical population: a total laryngectomy case series.
Regan J, Walshe M, Timon C, McMahon BP.
Clin Otolaryngol. 2015 Apr;40(2):121-9.


Do we really understand the role of the oesophagogastric junction in disease
BP McMahon, B A Jobe, J E Pandolfino, H Gregersen
World J Gastroenterology 2009: 15(2) 144-150


The functional lumen imaging probe (FLIP) for evaluation of the esophagogastric junction
BP McMahon, JB Frøkjær, P Kunwald, D Liao, P Funch-Jensen, AM Drewes, H Gregersen
Am J Physiol Gastrointest Liver Physiol. 2007:292(1):G377-84


Functional oesophago-gastric junction imaging
BP McMahon, H Gregersen, AM Drewes
World J Gastroenterol. 2006;12(18):2818-24


Regional variation in distal esophagus distensibility assessed using the functional luminal imaging probe (FLIP)
Lin Z, Nicodème F, Boris L, Lin CY, Kahrilas PJ, Pandolfino JE.
Neurogastroenterol Motil. 2013 Nov;25(11):e765-71


Effects of mosapride on esophageal motor activity and esophagogastric junction compliance in healthy volunteers
Fukazawa K, Furuta K, Adachi K, Moritou Y, Saito T, Kusunoki R, Uno G, Shimura S, Aimi M, Ohara S, Ishihara S, Kinoshita Y.
J Gastroenterol. 2014 Sep;49(9):1307-13  

Esophageal distensibility as a measure of disease severity in patients with eosinophilic esophagitis
Nicodème F, Hirano I, Chen J, Robinson K, Lin Z, Xiao Y, Gonsalves N, Kwasny MJ, Kahrilas PJ, Pandolfino JE.
Clin Gastroenterol Hepatol. 2013 Sep;11(9):1101-1107


Uses of Esophageal Function Testing: Dysphagia                                                                    ~
Yazaki E, Woodland P, Sifrim D                                                                                   
Gastrointest Endosc Clin N Am. 2014 Oct;24(4):643-54


Impaired fasting pyloric compliance in gastroparesis and the therapeutic response to pyloric dilatation.
Gourcerol G, Tissier F, Melchior C, Touchais JY, Huet E, Prevost G, Leroi AM, Ducrotte P.
Aliment Pharmacol Ther.
2015 Feb;41(4):360-7


Assessing pyloric sphincter pathophysiology using EndoFLIP in patients with gastroparesis
Malik Z, Sankineni A, Parkman HP.
Neurogastroenterol Motil. 2015 Apr;27(4):524-31


Esophagogastric junction distensibility in hiatus hernia
Lottrup C, McMahon BP, Ejstrud P, Ostapiuk MA, Funch-Jensen P, Drewes AM.~
Dis Esophagus. 2016 Jul;29(5):463-71


Functional lumen imaging of the gastrointestinal tract
Lottrup C, Gregersen H, Liao D, Fynne L, Frøkjær JB, Krogh K, Regan J, Kunwald P, McMahon BP.
J Gastroenterol. 2015 Oct;50(10):1005-16


Utilizing functional lumen imaging probe topography to evaluate esophageal contractility during volumetric distention: a pilot study 
Carlson DA, Lin Z, Rogers MC, Lin CY, Kahrilas PJ, Pandolfino JE.         
Neurogastroenterol Motil. 2015 Jul;27(7):981-90.

The Functional Lumen Imaging Probe Detects Esophageal Contractility Not Observed With Manometry in Patients With Achalasia
Carlson DA, Lin Z, Kahrilas PJ, Sternbach J, Donnan EN, Friesen L, Listernick Z, Mogni B, Pandolfino JE.
Gastroenterology. 2015 Dec;149(7):1742-51                                                                                                                                                                                                            

Evaluation of the pylorus with concurrent intraluminal pressure and EndoFLIP in patients with nausea and vomiting
Snape WJ, Lin MS, Agarwal N, Shaw RE.
Neurogastroenterol Motil. 2016 May;28(5):758-64   


Effects of Metoclopramide on Esophageal Motor Activity and Esophagogastric Junction Compliance in Healthy Volunteers
Mikami H, Ishimura N, Fukazawa K, et al.
J Neurogastroenterol Motil. 2016 Jan 31;22(1):112-7


A new evaluation of the upper esophageal sphincter using the functional lumen imaging probe: a preliminary report.
Regan J, Walshe M, Rommel N, McMahon BP.
Dis Esophagus. 2013 Feb-Mar;26(2):117-23


Severity of endoscopically identified esophageal rings correlates with reduced esophageal distensibility in eosinophilic esophagitis.
Chen JW, Pandolfino JE, Lin Z, Ciolino JD, Gonsalves N, Kahrilas PJ, Hirano I
Endoscopy. 2016 May 20;48:794-801


Evaluation of esophageal distensibility in eosinophilic esophagitis: an update and comparison of functional lumen imaging probe analytical methods      
Carlson DA, Lin Z, Hirano I, Gonsalves N, Zalewski A, Pandolfino JE.       
Neurogastroenterol Motil. 2016 Jun 16. doi: 10.1111/nmo.12888. [Epub ahead of print]


Esophagogastric junction distensibility identifies achalasia subgroup with manometrically normal esophagogastric junction relaxation.
Ponds FA, Bredenoord AJ, Kessing BF, Smout AJ
Neurogastroenterol Motil. 2016 Jul 25. doi: 10.1111/nmo.12908. [Epub ahead of print]


Comparison of videofluoroscopy and impedance planimetry for the evaluation of oesophageal stenosis: a retrospective study
Scharitzer M, Lenglinger J, Schima W, Weber M, Ringhofer C, Pokieser P.
Eur Radiol. 2016 Aug 23. [Epub ahead of print]


Emerging roles of the Endolumenal Functional Lumen Imaging Probe (EndoFLIP) in Gastrointestinal Motility Disorders.
Lawenko RM, Lee YY
J Neurogastroenterol Motil. 2016 Dec 23. doi: 10.5056/jnm16171. [Epub ahead of print]


Functional Lumen Imaging Probe forthe Management of Esophageal Disorders:Expert ReviewFrom the Clinical Practice Updates Committee of the AGA Institute.
Hirano I, Pandolfino JE, Boeckxstaens GE
Clin Gastroenterol Hepatol. 2017 Mar;15(3):325-334. doi: 10.1016/j.cgh.2016.10.022


The Role of Impedance Planimetry in the Evaluation of Esophageal Disorders.
Ahuja NK, Clarke JO.
Curr Gastroenterol Rep. 2017 Feb;19(2):7. doi: 10.1007/s11894-017-0544-2. Review


Evaluation of Esophageal Motility Utilizing the Functional Lumen Imaging Probe.
Carlson DA, Kahrilas PJ, Lin Z, Hirano I, Gonsalves N, Listernick Z, Ritter K, Tye M, Ponds FA, Wong I, Pandolfino JE.
Am J Gastroenterol. 2016 Dec;111(12):1726-1735. doi: 10.1038/ajg.2016.454


Esophagogastric junction distensibility assessed using the functional lumen imaging probe
Chen JW, Rubenstein JH
World J Gastroenterol. 2017 Feb 21;23(7):1289-97


Functional lumen imaging probe: The FLIP side of esophageal disease
Carlson DA
Curr Opin Gastroenterol. 2016 Jul;32(4):310-8


Clinical utility of a functional lumen imaging probe in management of dysphagia following head and neck cancer therapies.
Wu PI, Szczesniak MM, Maclean J, Choo L, Quon H, Graham PH, Zhang T, Cook IJ.
Endoscopy. 2017 May 31. doi: 10.1055/s-0043-110670. [Epub ahead of print]


Esophageal distensibility measurement: impact on clinical management and procedure length
Ahuja NK, Agnihotri A, Lynch KL, Hoo-Fat D, et al
Dis Esophagus (2017) 30 (8): 1-8.


Esophagogastric junction in systemic sclerosis: A study with the functional lumen imaging probe.
Fynne L, Liao D, Aksglaede K, Lottrup C, Gregersen H, Bjerregaard NC, Drewes AM, Krogh
Neurogastroenterol Motil. 2017 May 3. doi: 10.1111/nmo.13073. [Epub ahead of print]


Application of the Functional Lumen Imaging Probe to Esophageal Disorders.
Carlson DA, Hirano I.
Curr Treat Options Gastroenterol. 2017 Mar;15(1):10-25.

Therapeutic Endoscopy

Esophageal dilation with integrated balloon imaging: initial evaluation in a porcine model
O’Dea, P.D. Siersema
Therapeutic Advances in Gastroenterology 2013: 6(2) 109–114

Hydraulic dilation with a shape-measuring balloon in idiopathic achalasia: a feasibility study
Kappelle WF, Bogte A, Siersema PD
Endoscopy. 2015 Nov;47(11):1028-34.

Esophagogastric junction distensibility in the management of achalasia patients: relation to treatment outcome
Smeets FG, Masclee AA, Keszthelyi D, Tjwa ET, Conchillo JM
Neurogastroenterol Motil. 2015 Oct;27(10):1495-503.

Dilation in Achalasia – is normal distensibility enough ? and Authors reply
O Dea J. and Smeets FG, Masclee AA, Keszthelyi D, Tjwa ET, Conchillo JM.
Neurogastroenterol Motil. 2016 Jan;28(1):153-5. doi: 10.1111/nmo.12707 / doi: 10.1111/nmo.12729

Esophagogastric junction distensibility measurements during hydraulic dilation therapy in achalasia patients.
Kappelle WF, Bogte A, Siersema PD.
Expert Rev Med Devices. 2016;13(2):123-8

Lower GI Applications

Evaluation of anal sphincter resistance and distensibility in healthy controls using EndoFLIP
Alqudah MM, Gregersen H, Drewes AM, McMahon BP
Neurogastroenterol Motil. 2012:24(12) e591-9


Distensibility of the anal canal in patients with idiopathic fecal incontinence: a study with the Functional Lumen Imaging Probe.
Sørensen G1, Liao D, Lundby L, Fynne L, Buntzen S, Gregersen H, Laurberg S, Krogh K.
Neurogastroenterol Motil. 2014 Feb;26(2):255-63.


Distensibility of the anal canal in patients with systemic sclerosis: A study with the Functional Lumen Imaging Probe.
Fynne L, Luft F, Gregersen H, Buntzen S, Lundby L, Lundager F, Laurberg S, Krogh K.
Colorectal Dis. 2013:15(1) e40-7


Functional luminal imaging probe: a new technique for dynamic evaluation of mechanical properties of the anal canal.
Luft F, Fynne L, Gregersen H, Lundager F, Buntzen S, Lundby L, Laurberg S, Krogh K.
Tech Coloproctol. 2012:16(6) 451-7


Do endoflip assessments of anal sphincter distensibility provide more information on patients with fecal incontinence than high-resolution anal manometry?
Gourcerol G, Granier S, Bridoux V, Menard JF, Ducrotté P, Leroi AM.
Neurogastroenterol Motil. 2016 Mar;28(3):399-409

Increased yield pressure in the anal canal during sacral nerve stimulation: a pilot study with the functional lumen imaging probe. 
Haas S, Liao D, Gregersen H, Lundby L, Laurberg S, Krogh K.
Neurogastroenterol Motil. 2016 Aug 21. doi: 10.1111/nmo.12929. [Epub ahead of print]

MR-FLIP: A new method that combines FLIP with anatomical information for the spatial compliance assessment of the anal sphincter muscles.

Brusa T, Abler D, Tutuian R, Studer P, Fattorini E, Gingert C, Heverhagen JT, Brügger LE, Büchler P.
Colorectal Dis. 2016 Dec 20. doi: 10.1111/codi.13588. [Epub ahead of print]

Interventional Cardiology

Assessment of annular distensibility in the aortic valve
John O’Dea; David J. Nolan
Interactive CardioVascular and Thoracic Surgery 2012:15(3) 361-3


Cervical Stiffness Evaluated In Vivo by Endoflip in Pregnant Women
Hee L, Liao D, Sandager P, Gregersen H, Uldbjerg N
PLoS ONE (2014) 9(3): e91121.doi:10.1371/journal.pone.0091121

Pediatric Populations

Intraoperative Functional Luminal Imaging to Assess Esophagogastric Junction Distensibility during Per-Oral Endoscopic Myotomy in Pediatric Patients
Wright R, Chao S, Wall J
J Gastroint Dig Syst 2014, 4:4
Surgical Management of Esophageal Achalasia: Evolution of an Institutional Approach to Minimally Invasive Repair
Petrosyan M, Khalafallah A, Guzzetta P, Sandler A, Darbari A, Kane T
Journal of Pediatric Surgery (2016), doi: 10.1016/j.jpedsurg.2016.05.015 [Epub ahead of print]

Influence of Age and Eosinophilic Esophagitis on Esophageal Distensibility in a Pediatric Cohort.
Menard-Katcher C, Benitez AJ, Pan Z, Ahmed FN, Wilkins BJ, Capocelli KE, Liacouras CA, Verma R, Spergel JM, Furuta GT, Muir AB.
Am J Gastroenterol. 2017 May 16. doi: 10.1038/ajg.2017.131. [Epub ahead of print]

Note : The above references describe a variety of different uses of the EndoFLIP system, some of which may or may not have received regulatory clearances in certain territories. Please see Regulatory Information and approved product labelling at User Manuals for a full list of approved indications of use in different territories.

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